Gunbuster

In the very near future, a race of huge, insect like aliens is discovered traveling the galaxy. These aliens seem dedicated to the eradication of the human species as it takes its first steps away from the solar system, and they are getting closer and closer to Earth. Humanity has responded by developing spacegoing battleships and giant fighting robots. These robots are piloted by the best and brightest of Earth's youth, picked from training schools around the world. The story begins in the year 2023, not long after the first battles with the aliens, and centers on young Noriko Takaya. Although Noriko's father was a famous Captain in the space fleet who was killed during one of the first battles of the war, her own talents as a pilot are questionable. Nonetheless, she has entered a training school. Through the series Noriko, joined by the beautiful and talented Kazumi Amano, will fight to overcome the trauma of war, the doubts of her peers, and her own lack of confidence. (Source: AniDB)

ANEMONE: Eureka Seven Hi-Evolution

Seven years ago, Anemone’s father disappears, leaving his daughter with nothing but an app on her phone to support her. Now, she’s tasked with a pivotal role in the war against mankind’s enemy - a war which sees her subconscious sent into the midst of another world as humanity’s only truly effective weapon. As unusual events within this other world unfold, so more and more questions are raised about Anemone’s life, as well as the nature of what she is truly fighting against. With seemingly endless possibilities stretching out before her, Anemone has an important choice to make - does she save the world, or the person she loves?

Star Blazers: The Quest for Iscandar

In the distant future, the war between the human race and the Gamilon has taken its toll on the planet Earth. Constant bombardment of radioactive asteroids has rendered the planet's atmosphere uninhabitable. As a means of relief aid, Queen Starsha of the planet Iscandar offers the Earth Forces a device that can completely neutalize the radiation off the planet. For this task, the space battleship Yamato is launched from the remains of its World War II ancestor on a 148,000 light-year journey. However, the crew of the Yamato has only one Earth year to travel to Iscandar and back, or the human race will come to an end. (Source: Anime News Network)

Nadia: The Secret of Blue Water

In 1889, the world is on the pinnacle of great discoveries in technology. In mankind's grasp for the future, a sinister foe known only as Gargoyle, obsessed with restoring the former Atlantean empire to the glory it once held, begins his plans to take over the world. Nadia, with the help of a young inventor, Jean Raltique, and the mysterious captain Nemo of the submarine Nautilus, must fight to save the world from Gargoyle and Neo-Atlantis. Based on the Novel '20,000 Leagues Under the Sea' by Jules Verne. (Source: Anime News Network)